Grapes increase microbiota diversity and lower colesterol. Grapes contain polyphenols, flavonoids, and are a good source of fiber. Fruits high in these phytochemicals have been shown to have prebiotic effects, causing changes in the composition of the gut microbiota.

Dysbiosis -imbalance in the intestinal flora- has been associated with the development of metabolic diseases, such as obesity, type 2 diabetes mellitus and cardiovascular diseases. There is increasing evidence suggesting a crucial role for these particles in host cholesterol homeostasis and bile acid metabolism.

Bacteria Akkermansia degrades mucin, which stimulates goblet cells to produce more, increasing protection of the intestinal barrier and preventing dysbiosis.

Dietary intervention is the main approach to cholesterol control. Soluble fiber, 2 to 10 g daily, is associated with a small but significant decrease in the general index and LDL.

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